Upon co-culture with CRISPR/nCas9-edited CD34+ cells, we observed a reduction in the mitochondrial mass of 28% in co-cultured MPS IVA fibroblasts, compared to untreated MPS IVA fibroblasts (Figure 4c), suggesting amelioration in the mitochondrial mass of MPS IVA fibroblasts. The gene discussed is CD34; the disease is mucopolysaccharidosis type 4A.