However, a study has revealed that the conditional knockout of BAT3 (TIM3 adapter protein) in DCs leads to reduced numbers of tumor-infiltrating Th1, Th17, and cytotoxic effector cells, while increasing the number of Treg cells and depleting tumor-infiltrating CD8+ T cells, ultimately weakening the immune response and accelerating tumor growth [22]. This evidence concerns the gene CD8A and neoplasm.