Vascular endothelial growth factor-A (VEGF-A)165 elevates the permeability of the endothelial cell (EC) layer of retinal microvessels, eventually resulting in vision-threatening macular edema, a hallmark of burdening retinal diseases such as age-related macular degeneration, diabetic macular edema, retinal vein occlusion, and myopic retinopathy [1,2,3]. The gene discussed is VEGFA; the disease is age-related macular degeneration.