TNF and graft versus host disease: Conversely, in the GVHD, two other clusters emerged: the cluster formed by IL-1β, IL-6, TNF-α, CD27, TRAIL-R2, CCL2, and CXCL8 negatively correlated with the cluster comprising IL-4, IL-1Ra, IL-17, FGF, β2-MG, GM-CSF, CCL3, CCL4, CCL5, and CXCL5 (Figure 10A).