Our ongoing research focuses on investigating the potential bioactive phytochemical constituents of the Congolese Croton species extracts, with particular emphasis on evaluating the predicted binding affinity of isolated terpenoids to two structurally characterized receptors—the human androgen receptor (HAR, PDB ID: 1E3G) and hypoxia-inducible factor 1-alpha (HIF-1α, PDB ID: 3KCX), associated with PC-3 and MCF-7 cancer cell lines, respectively, through molecular docking studies. This evidence concerns the gene HIF1A and cancer.