TGFB1 and colorectal carcinoma: Finally, as C-MYC up-regulation is amplified by EGFR signaling in murine models of CRC [25], the combined use of ULD of TGF-β, EGF, and SNA-MYC in 2LC1 is intended to downregulate their associated pathways, counteracting the uncontrolled cancer cell proliferation.