As CD86 and HLA-DR are two markers that are expressed by anti-tumor M1 macrophages [37], their expression was at first appraised in M2c, in “M2c > M1”-switched, and in M1 control macrophages, to confirm that the expression of these markers was higher in M1 than in M2c (Supplementary Figure S7). This evidence concerns the gene CD86 and neoplasm.