AβPP can be cleaved via two pathways: the non-amyloidogenic pathway involves α- and γ-secretases, producing soluble fragments, while in the amyloidogenic pathway, β-secretase first cleaves AβPP, followed by γ-secretase, releasing the Aβ fragment associated with Alzheimer’s disease [208]. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.