There are cases where such an imbalance has led directly to psychopathology; parallel data in mood and anxiety disorders had there been the identification of BDNF as a candidate gene in mood disorders in individuals carrying the met allele, who have a reduced activity-dependent BDNF release and, therefore, increased susceptibility to stress-induced mood disorders, and there would be indicated a possible mechanism in which signaling compensatory upregulation may prove advantageous [268]. This evidence concerns the gene BDNF and mood disorder.