Neuronal protection, as well as functional recovery, can be induced in PD by targeting certain regulatory elements using CRISPR-Cas9, as well dCas9-mediated histone acetylation is an example of a robust epigenetic editing tool capable of etching stable activation of transcriptional priority with a regulative capacity capable of restoring BDNF deficits common in mood and stress-related disorders [325]. The gene discussed is BDNF; the disease is Parkinson disease.