NFKB1 and atherosclerosis: Polymethoxyflavones (PMFs) from aged citrus peel support the increase in beneficial bacteria such as Akkermansia and Bifidobacterium, inhibit the production of TMA by targeting TMA-producing bacteria and hepatic FMO3, and decrease the NF-κB/MAPK signaling pathways, thus preventing vascular inflammation and atherosclerosis (AS) formation [214].