Furthermore, MCs-secreted TGF-β can reshape the tumor microenvironment, fostering fibrosis or desmoplasia by stimulating the proliferation and collagen production of fibroblasts, differentiating them into cancer-associated fibroblasts (CAFs), a critical event for metastasis, as well as it can promote local secretion of diverse cytokines and chemokines [13,20]. Here, TGFB1 is linked to cancer.