In this study, we compared blood plasma lipids and LDLR deletion levels of Exon4 and Exon12 in leukocytes from physically active or aerobic-exercise-trained people and less physically active or non-trained people with normal and high cholesterol levels, since these two missing variant spliceosomes are strongly associated with hypercholesterolemia [10,11]. Here, LDLR is linked to Hypercholesterolemia.