APP and Alzheimer disease: To distinguish between the two categories of AD and their respective triggers, the disease initiated by AβPP-derived iAβ has been referred to as “conventional AD” and its trigger, AβPP-derived iAβ, as the “conventional stressor”, whereas the disease triggered by stressors (any stressors) distinct from AβPP-derived iAβ was designated as “unconventional AD” and stressors triggering it have been referred to as “unconventional stressors”.