APP and early-onset autosomal dominant Alzheimer disease: Version Three of the ACH2.0 posits that in both, conventional and unconventional forms of Alzheimer’s disease the neuronal integrated stress response-caused suppression of the global cellular protein synthesis includes all constituents of the AβPP proteolytic pathway, namely AβPP, BACE enzymes, components of the gamma-secretase complex, and, consequently, Aβ and iAβ.