In Panel A of Figure 25, shown above, the duration of the operation of the unconventionally activated AβPP-independent C99/iAβ generation pathway is substantial yet AβPP-derived iAβ, accumulating from an elevated baseline following the withdrawal of the unconventional stressor, does not reach the T1 threshold within the lifetime of the individual, and no AD occurs. This evidence concerns the gene APP and Alzheimer disease.