Conceivably, such bursts, more appropriately “microbursts”, of unconventional activity of the AβPP-independent C99/iAβ production pathway may occur dozens of times during the lifetime of an individual, reflecting numerous episodes of viral or bacterial infection and of transient inflammation events, occurring without causing AD (because levels of iAβ remain below the T1 threshold and the AβPP-independent C99/iAβ production pathway does not attain self-sustainability) and thus remaining undetected and unconsequential. This evidence concerns the gene APP and bacterial infectious disease.