The causal relationship between cognitive impairments in mice overexpressing human AβPP and the neuronal ISR is illustrated by observations that prevention of the neuronal ISR in these mice prevents cognitive impairment and that inhibition of the neuronal ISR (and consequent restoration of cellular protein synthesis) abrogates impairment if it already occurred [119,120,121,122,123,124,125,126,127]. This evidence concerns the gene APP and Cognitive impairment.