As the following summary shows, ASIV reduces the proliferation, migration, and viability of various cancer cells, including breast, lung, colon, cervical, and liver cancers, often by inducing apoptosis and modulating key signaling pathways such as PI3K/AKT/mTOR, TGF-β1/FAK/AKT and AMPK. The gene discussed is AKT1; the disease is cancer.