KEAP1 and brain ischemia: Wang et al. [86] proposed the P62/Keap1/Nrf2 signaling pathway as the target of ASIV in the cerebral ischemia-reperfusion injury model, which attenuated the cell damage and sensorimotor dysfunction induced by OGD/R in rats, increased the levels of Nrf2 and p62 proteins, and decreased Keap1 levels.