The HSPC subpopulation capable of generating leukemia at diagnosis was found to be HSC-MPP33−-like, while the corresponding subpopulations at relapse were as follows: HSC-MPP33-like, harboring WT1, RUNX1, and STAG2 mutations; MLP33+-like carrying TP53, WT1, IDH1, and RUNX1 mutations as well as GMP33+-like exhibiting TP53, WT1, IDH1, RUNX1, and TET2 mutations (Figure 2A,C and Figure 6B). This evidence concerns the gene TET2 and leukemia.