HMGB1 and acute myeloid leukemia: Interestingly, our experiments with exogenous HMGB1 administration revealed no significant effects on preadipocyte proliferation or differentiation marker expression, which differs from the findings of Liu et al., who reported substantial HMGB1 effects on cell proliferation and myeloid differentiation in bone marrow mononuclear cells from relapsed acute myeloid leukemia patients [6].