Several studies have identified compounds that influence these pathways: (1) HMGB1 inhibitors: Glycyrrhizin, a natural HMGB1 antagonist, has been shown to attenuate oxidative stress, hepatic inflammation, and apoptosis in high fructose-fed rats, highlighting its therapeutic potential in liver dysfunction associated with metabolic syndrome [47]. This evidence concerns the gene HMGB1 and metabolic syndrome.