However, studies indicated that both early and late RU486 administration inhibited the elevated hippocampal FKBP4 level and hypothalamus GR level in a single prolonged stress rats in a posttraumatic stress disorder model [59], and early intervention with a GR antagonist aided in the correction of traumatic-stress-induced fear and anxiety dysregulation. The gene discussed is NR3C1; the disease is post-traumatic stress disorder.