Dazucorilant (CORT113176) is a GR antagonist, selective, and high.affinity non-steroidal GR modulator which lacks cross-reactivity with other steroid receptors, making it more selective than RU486 (Table 4), and it has been shown to be effective in Alzheimer’s and amyotrophic lateral sclerosis models [44]. This evidence concerns the gene NR3C1 and amyotrophic lateral sclerosis.