AKT1 and hepatocellular carcinoma: Although this study reveals that LPA/LPAR6 inhibits HCC cell proliferation and migration through the Hippo signaling pathway, it does not explore the interaction between LPA/LPAR6 and other cell signaling pathways (such as PI3K-AKT, MAPK, etc.), which could provide insight into how different signaling pathways collaborate to regulate tumor progression.