Yasuhiro et al. found that hydrogen molecules could inhibit the inflammatory response and fibrosis by reducing the levels of lipid peroxide in serum and 8-hydroxydeoxyguanosine in the lung tissue of rheumatoid arthritis-related ILD mice, thereby reducing the expression of inflammatory factors such as TNF-α, IL-6, and TGF-β in the lungs [28]. This evidence concerns the gene TGFB1 and rheumatoid arthritis.