HIF1A and Headache: When it comes to the central nervous system, chronic neuroinflammation and prolonged hypoxia, mediated by HIF-1α, may promote endothelial dysfunction and impairment of the blood–brain barrier, which exacerbates the production of inflammatory cytokines, intensifies oxidative stress and results in sustained neurological (such as mental fog and headache) and psychiatric (anxiety and depression) disorders [76,77].