Additionally, studies indicate that patients displaying co-expression of HIF-1α and interleukin-6 (serum IL-6 > 35 pg/mL) face an increased risk of progression from silent hypoxia to acute respiratory distress syndrome (ARDS), highlighting the intersection of hypoxic and inflammatory signaling in disease progression [68,70]. The gene discussed is HIF1A; the disease is acute respiratory distress syndrome.