To sum up, the mechanism of inflammation and oxidative stress leading to insulin resistance is still unclear, but at least it can be speculated that cytokines may activate different signaling pathways and then affect gene transcription in the nucleus, or increase intracellular oxidative pressure to form downstream serine, inhibit the IRS tyrosine phosphating reaction, and indirectly hinder the normal insulin signaling pathway. Here, INS is linked to Insulin resistance.