ARRB1 (p = 2.79 × 10−5), CTBP1 (p = 1.33 × 10−5) and CTBP2 genes (p = 0.0002) exhibited notable upregulation in adenoma, whereas COL1A2 (p = 0.0075), CEBPZ (p = 0.0057), MED10 (p = 0.0196) and PAWR genes (p = 0.00215) showed significant upregulation in adenocarcinoma. The gene discussed is CTBP2; the disease is adenocarcinoma.