IGHE and Alzheimer disease: The serum analysis revealed elevated levels of immunoglobulin E (IgE), histamine, mast cell-associated cytokines (interferon (IFN)-γ, TNF-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1β, and IL-6), and proinflammatory chemokines (MCP-1 and MIP-3α) in the AD group.