HMOX1 and Schnyder corneal dystrophy: Our group also conducted studies in SCD mice treated with another NRF2 activator dimethyl fumarate (DMF), which inhibits cytoplasmic sequestration of NRF2 by KEAP1 leading to nuclear translocation and activation of its downstream target gene HMOX1, and NQO1 among others (Figure 2) [21].