INS and Cognitive impairment: It is also noted that, although the i.c. STZ causes insulin deficiency with cognitive impairment and neurodegeneration, over time, i.c. STZ-treated animals exhibit body weight gains, hepatic steatosis (fatty liver), and peripheral insulin resistance [5,60], which likely account for the statistical trend-wise increases in liver and body weight observed herein in the i.c. STZ group.