GPX4 and hepatocellular carcinoma: We also assessed the effect of miR-142-3p overexpression on ferroptosis, a form of cell death that is characterized by iron dependency and lipid peroxidation, and has emerged as a promising therapeutic target in HCC [14], by examining the expression of glutathione peroxidase 4 (GPX4), a key factor in inhibiting ferroptosis, and found its levels to be significantly reduced with miR-142-3p overexpression (Figure 2H).