In HCC, miR-142-3p has multiple specific functions, including promoting ferroptosis, inhibiting metastasis, sensitizing cells to sorafenib, and modulating key oncogenes (e.g., high-mobility group box 1 [51]) and metabolic enzymes (e.g., lactate dehydrogenase A [50]) [51,52,53,54]; however, the precise mechanisms by which miR-142-3p modulates liver cancer progression and therapeutic resistance remains to be elucidated. This evidence concerns the gene LDHA and liver cancer.