To explore the role of YES1 in HCC we used specific siRNAs (siYES1 #6 and siYES1 #7) to transiently knockdown YES1 in inherent (SNU475, PLC/PRF/5) and acquired (Huh-7/LR, Huh-7/SR1) TKI-resistant HCC cells, and observed a significant inhibition of proliferation in all cell lines with YES1 reduction (Figure 5A/Figure S5C). Here, YES1 is linked to hepatocellular carcinoma.