AKT1S1 and cancer: These genes are involved in diverse cellular functions relevant to cancer biology: WASL (Wiskott–Aldrich syndrome like) regulates actin cytoskeleton remodeling and cell motility [23]; AKT1S1 (also known as PRAS40) is a substrate of AKT and modulates mTORC1 activity [24]; TWF1 (twinfilin-1) is an actin-binding protein that controls cytoskeletal dynamics and contributes to EMT [25]; and YES1 is an Src family tyrosine kinase involved in survival signaling, cell proliferation, and drug resistance [26].