Since our study focused on the direct regulatory effects of miR-142-3p within HCC cells, we selected YES1 and TWF1 for in-depth investigation based on their established involvement in survival signaling, autophagy, and cytoskeletal remodeling—key processes that underlie adaptive drug resistance and escape mechanisms in multiple cancers [25,31,32,33]. The gene discussed is YES1; the disease is hepatocellular carcinoma.