Based on this evaluation, we analyzed the expression of nine additional genes—ASH1L, ITGB8, PLCB1, VAMP3, RARG, NR2F6, CFL2, LRRC32, and MRFAP1—using the BIOSTORM HCC cohort data, comparing sorafenib responders versus non-responders. This evidence concerns the gene ITGB8 and hepatocellular carcinoma.