Here, using an in silico approach, we identified miR-142-3p as a miRNA with therapeutic potential in HCC, with its overexpression resulting in a marked reduction in HCC cell line proliferation, colony formation, migration/invasion, as well as decreased expression of EMT-associated genes (e.g., VIM, CDH2, SNAI2, ZEB1, and ZEB2), and an increase in cell cycle arrest and apoptosis. This evidence concerns the gene ZEB2 and hepatocellular carcinoma.