In aortic endothelial cells, Slit2 suppresses tumor necrosis factor (TNF)-α-induced vascular endothelial cell proliferation and migration in vitro by inhibiting the vascular endothelial growth factor (VEGF)-Notch signaling pathway [56], meaning the hypermethylation of SLIT2 promoter region and its subsequent suppression means the promotion of TNF-α-induced vascular endothelial cell proliferation and migration, overall abetting tumor progression. Here, TNF is linked to neoplasm.