Alajez et al. used an integrated tri-modality approach to identify targets for miR-218 in NPC, who subsequently validated direct integrations between miR-218 and the 3′-untranslated regions (UTR) of mRNAs encoding Roundabout Guidance Receptor 1 (ROBO1), survivin (BIRC5), and connexin43 (GJA1) using luciferase-based transcription reporter assays [37]. Here, ROBO1 is linked to nasopharyngeal carcinoma.