Notably, miR-218-5p was severely downregulated in AP, as well as in CRC, and found to regulate CRC via targeting key tumor-promoting genes, including Baculoviral IAP Repeat Containing 5 (BIRC5), encoding Survivin, and DExD-Box Helicase 21 (DDX21). This evidence concerns the gene DDX21 and colorectal carcinoma.