In this work, taking advantage of the nematode model, we aimed to explore the therapeutic potential of H. citrina Baroni flower extracts in genetic models of MJD/SCA3—a genetically inherited spinocerebellar ataxia caused by an abnormal expansion of a CAG in the ATXN3 gene—and frontotemporal dementia with parkinsonism associated with chromosome 17 (FTDP-17)—a genetically determined form of dementia caused by mutation in the microtubule-associated protein tau (MAPT) gene [11,12,13,14]. Here, MAPT is linked to dementia.