Considering the findings indicating that HCE effects in MJD/SCA3 depended on serotonergic signaling and that this extract induced HLH-30/TFEB nuclear translocation (Figure 4 and Figure 6), we next investigated whether HLH-30/TFEB activation was also controlled by serotonergic signaling. Here, ATXN3 is linked to Spinocerebellar ataxia type 3.