In this study, we showed that a chronically applied extract derived from an Asian edible plant, H. citrina Baroni, improved, in a dose-dependent manner, the motor phenotypes of two animal models of genetically determined NDs: MJD/SCA3, caused by mutant ataxin-3, and FTDP-17, determined by a mutant form of the Tau protein. This evidence concerns the gene ATXN3 and Spinocerebellar ataxia type 3.