Biallelic mutations in LAMA3, LAMB3, and LAMC2 cause junctional epidermolysis bullosa with severe enamel hypoplasia in humans [18,19,20,21], while single allelic defects in LAMA3 [22,23,24] and LAMB3 [25,26,27,28,29] cause localized enamel defects without skin fragility. This evidence concerns the gene LAMA3 and dental enamel hypoplasia.