The significant interaction characteristics of genes such as RUNX2 [43,44] and TGFB2 [45,46] also suggest that abnormal bone and soft tissue remodeling may participate in the pathophysiological process of tinnitus, which is consistent with the degenerative changes in the bony labyrinth structure of the inner ear after radiotherapy. Here, TGFB2 is linked to Tinnitus.