However, the induction of diabetes was also observed in 100% of HPSE-1-deficient RIP-OVAhi recipient mice that received WT OT T cells, despite a significant difference in exocrine tissue histology between WT and HPSE-1-deficient RIP-OVAhi mice (p = 0.008, Score 5, WT versus HPSE-1-deficient hosts) (Figure 5b and Figure 6b). Here, HPSE is linked to diabetes mellitus.