HPSE and diabetes mellitus: Based on the optimal cell dose required for acinar and islet tissue inflammation as well as diabetes induction previously identified (Figure 1 and Figure 3), these molecular studies utilized the adoptive transfer of 2 × 106 naïve wildtype (WT) or HPSE-1 deficient OTI cells and activated OTI cells to WT or HPSE-1 deficient RIP-OVAhi mice.