RGS14 and obesity due to melanocortin 4 receptor deficiency: An additional major finding was that the BAT from the RGS14 KO mouse mediated these effects of protection against obesity and glucose intolerance, since removing BAT from the RGS14 KO mouse eliminated the protection, and when BAT was transplanted to WT mice, the protection against obesity and glucose intolerance was recapitulated in the WT mice recipients of the transplanted BAT.