CFL1 and cancer: The established role for cofilin in migration, invasion, epithelial-mesenchymal transition (EMT), apoptosis, radiotherapy and chemotherapy resistance, immune escape, and transcriptional dysregulation of malignant tumors [22] is explained mainly by the cofilin-controlled mechanic activity of cells, like proliferation [36], cell migration [16,36,37,38,39,40], cell adhesion [41,42], and colony formation [31].