HAVCR2 and neoplasm: Numerous processes responsible for acquired resistance to treatment have been described, such as the compensatory induction of alternative pathways, such as mucin domain protein 3 (TIM-3), lymphocyte activation gene 3 (LAG-3), decrees radio of TILs (tumor-infiltrating lymphocytes) to Tregs and MDSCs, immunoediting with loss of neoantigens, or aberrant WNT/beta-catenin signaling [15,16].