The ligands for LAG-3 in the tumor microenvironment are MHC II (major histocompatibility complex class II), galactose-lectin-3 (Galectin-3), hepatic sinusoidal endothelial cell lectin (LSECtin), fibrinogen-like protein 1 (FGL1), and α-synuclein. This evidence concerns the gene LAG3 and neoplasm.