Treatment with 5,14-HEDGE in rat arteries activated GPR75 downstream pathways, including Gαq/11/PKCα/MaxiKβ, GIT1/PKCα/MaxiKβ, GIT1/c-Src/MaxiKβ, and GIT1/c-Src/EGFR, while AAA effectively reversed these effects. This evidence concerns the gene SRC and triple-A syndrome.