GPR75 and prostate cancer: Cárdenas et al. [37] reported GPR75 expression in prostate cancer PC-3 cells, where 20-HETE significantly increased hydrogen peroxide-inducible clone-5 (HIC-5) protein expression, a key downstream GPCR signaling molecule, as well as EGFR, NF-κB, AKT, and p38 MAPK phosphorylation.