Additionally, 20-HETE’s vasoconstrictive and diuretic effects have been linked to the PLC/PKC pathway, and its effects on vascular smooth muscle cell (VSMC) migration, endothelial dysfunction, and inflammation appear to involve the c-Src/EGFR pathway [34], which is commonly activated by GPCRs [35]. The gene discussed is EGFR; the disease is endothelial dysfunction.