GPR75 and neoplasm: Recently, Chen et al. [39] found in human fetal lung fibroblast cell line MRC5 and mouse fibroblast cell line L929 that 20-HETE upregulates GPR75 expression, and that knocking down Gpr75 effectively inhibits the 20-HETE-induced expression of tumor immune evasion factors, such as α-smooth muscle actin (α-SMA), fibroblast activation protein-α (FAP), programmed death-ligand 1 (PD-L1), interleukin 6 (IL-6), and transforming growth factor-β (TGF-β).