In-depth exploration of GPR75’s oligomerization dynamics and intracellular localization will not only reveal novel mechanisms by which this receptor regulates cardiovascular homeostasis, energy metabolism, and synaptic plasticity but also establish a theoretical foundation for developing biased drugs targeting GPR75, which is of significant value in treating major diseases, such as obesity, Alzheimer’s disease, and cancer. This evidence concerns the gene GPR75 and Obesity.