GPR75 and Hypertension: Recent studies indicate that GPR75 may also bind to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite of cytochrome P450 (CYP450) enzymes [6,7], highlighting its roles in the nervous, cardiovascular, and endocrine systems and its potential involvement in neurodegenerative diseases, hypertension, and metabolic syndrome.