To confirm GPR75’s role in obesity suppression, the study observed that in a high-fat-diet (HFD)-induced obesity model, untreated mice nearly doubled their weight over 14 weeks, whereas heterozygous (Gpr75+/−) mice gained 25% less and homozygous (Gpr75−/−) mice gained 45% less weight. Here, GPR75 is linked to obesity due to melanocortin 4 receptor deficiency.