Similarly, in endothelial cells, 20-HETE’s interaction with GPR75 activated G protein-coupled receptor kinase interactor 1 (GIT1), inducing EGFR phosphorylation and activating the NF-κB pathway, which increased angiotensin-converting enzyme (ACE) expression and contributed to endothelial dysfunction. Here, GIT1 is linked to endothelial dysfunction.