IL11 and Hepatic fibrosis: A research team also constructed NP-AEAA-coated siRNA (si@NP-AEAA) using nanoparticle NP-AEAA, which is predominantly target-enriched in aHSCs, to regulate HSC activation and fibrotic remodeling by blocking IL-11/ERK signaling in a mouse model of hepatic fibrosis’ increased IL-11 expression.