The role and regulatory mechanism of tumor-derived exosomal AFAP1-AS1 (actin filament-associated protein 1 antisense RNA 1) in pituitary adenomas was the subject of a study by Tang et al. AFAP1-AS1 is a long non-coding RNA overexpressed in several cancers, playing a critical role in tumor proliferation. This evidence concerns the gene PTGDR and neoplasm.