They presented a novel concept of intercellular communication, according to which invasive NF-PitNETs cells specifically selected MMP1 (matrix metalloproteinase-1) mRNA and protein for uptake into the exosomal vesicle and transferred MMP1 activity to acceptor cells, including other tumor and vascular endothelial cells, that may well have vital functions in stimulating tumor invasion and angiogenesis. This evidence concerns the gene MMP1 and neoplasm.