They demonstrated that the expression level of exosomal H19 in all subtypes of pituitary tumors was significantly lower, and the exosomal H19 could be transported across the cell membrane to exert its inhibitory effect on pituitary tumor growth through inhibiting phosphorylation of the mTORC1 substrate 4E-BP1. The gene discussed is EIF4EBP1; the disease is pituitary tumor.