Previously, authors demonstrated Aβ expression, Tau protein phosphorylation, and the suppression of genes associated with learning, memory, and synaptic plasticity, including the gene of brain neurotrophic factor (exon Bdnf IV) and Homer1, on a human nerve cell culture that consisted of a neuroblastoma cell line overexpressing human APP with FAD double mutations [33]. Here, APP is linked to neuroblastoma.