NR1H4 and major depressive disorder: Haoran Zhang et al. [33] found that ganoderic acid A can inhibit NLRP3 inflammasome activity in the prefrontal cortex of a social defeat stress model in mice by regulating FXR, impacting the activation and release of caspase-1 and IL-1β, enhancing AMPA receptor surface stability in the hippocampus, and further promoting glutamatergic neurotransmission in the hippocampal region, ultimately alleviating depression-like behaviors in mice.