Overall, in various types of cancer, such as breast, prostate, ovarian, lung, colorectal, pancreatic, and hepatocellular carcinoma, as well as in glioma, melanoma, anaplastic large cell lymphoma, and chronic myelogenous leukemia, there has been an increase in the expression of p130Cas and Crk/CrkL. Here, CRKL is linked to chronic myelogenous leukemia, BCR-ABL1 positive.