RAC1 and lung adenocarcinoma: In addition, the induction of EMT in A549 human lung adenocarcinoma cells by Crk was mediated through the distinct regulation of the Rac1/Snail and RhoA/Slug signaling pathways, which led to a decrease in E-cadherin expression alongside increased levels of N-cadherin, fibronectin, and MMP2 [122].