In inflammatory bowel disease, the expression levels of pro-inflammatory factors like IL-6 and TNF-α are increased and NF-κB are activated [19,20,21], revealing that the NF-κB signaling pathway and anti-inflammatory methods to protect the colon tissue from damage caused by excessive inflammatory response also play an important role in the body’s life activities. The gene discussed is NFKB1; the disease is inflammatory bowel disease.