GB1 can reduce the mRNA and protein expression levels of NLRP3, ASC, caspase-1, and IL-1β in the tissues of colitis mice, but these effects of Nlrp3-/- mice are abolished, indicating that GB1 has the ability to inhibit the activation of NLRP3 inflammatory bodies, reduces the production of pro-inflammatory factors and improves t-he inflammation of the colon of mice. The gene discussed is GABBR1; the disease is colitis.