ID1 then interacts with ring finger protein 4 (RNF4), an E3 ubiquitin ligase, curtails specificity protein 1 (SP1) ubiquitination, and increases the expression and secretion of angiopoietin-like protein 7 (ANGPTL7), thus advancing AML [72]. This evidence concerns the gene ANGPTL7 and acute myeloid leukemia.