Furthermore, to enhance the pathological properties of α-synuclein, we inserted an A53T mutation into SNCA and two single-nucleotide polymorphisms identified in a genome-wide association study in Parkinson’s and a Rep1 polymorphism, all of which are causal of familial Parkinson’s disease or increase the risk of sporadic Parkinson’s disease. The gene discussed is CHM; the disease is Parkinson disease.