First, in this study, we conducted a differential expression analysis based on the expression of CRDRGs in sepsis and control groups, and we obtained a total of 16 DEGs (PER1, PER3, CLOCK, CRY1, CRY2, TIMELESS, BMAL1, CSNK1D, NR1D1, CSNK1E, NPAS2, DBP, RORA, BHLHE40, AANAT, and FBXL3). This evidence concerns the gene NR1D1 and Sepsis.