Bulk RNA sequencing and Gene Set Enrichment Analysis (GSEA) revealed that BMP4-treated cells showed a significant enrichment of gene sets related to cellular senescence and the mesenchymal (MES) GBM subtype—ranking among the top 20 of 2389 gene sets from the MSigDB chemical and genetic perturbations collection—alongside a reduction in proliferation-related transcripts and proneural (PN) GBM markers (Supplementary Table S1). Here, BMP4 is linked to glioblastoma.