It also induces the angiotensin II type 1 receptor (AT1R) and angiotensin II receptor type 2 (AT2R), leading to overactivation of the RAAS and AngII/AT1R/NOX pathway, resulting in the elevation of oxidative stress, induction of the MAPK pathway, and cardiac hypertrophy [161]. Here, AGTR1 is linked to cardiac hypertrophy.