In this content, VDAC1 overexpression has been implicated in many diseases including cancer, Alzheimer’s disease (AD) [69,70,71,72], Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) [73,74], type 2 diabetes (T2D) [75,76,77], cardiovascular diseases [78,79], and autoimmune diseases [80]. This evidence concerns the gene VDAC1 and Alzheimer disease.