To evaluate the potential of SH3YL1 and NOX4 as diagnostic biomarkers for bladder cancer subtypes, we conducted ROC (Receiver Operating Characteristic) curve analysis on SH3YL1, NOX4, and the combined SH3YL1 + NOX4 expression levels in NMIBC and MIBC groups. The gene discussed is SH3YL1; the disease is urinary bladder cancer.