While we did not observe significant differential expression of ribosomal proteins in ETV6::RUNX1+ and TCF3::PBX1+ BM biopsies, our findings underscore the need for further investigation into subtype-specific export of ribosomal protein genes within circulating sEVs derived from the blood of childhood B-ALL patients. This evidence concerns the gene ETV6 and precursor B-cell acute lymphoblastic leukemia.