Looking for the underlying mechanisms for astrocyte DJ-1 anti-oxidation function and its effects on miR-155 and SHP-1 (Src homology 2 domain-containing phosphatase-1), investigators found that DJ-1 inhibited the transition of astrocytes to the harmful A1 phenotype and promoted A2 polarization, suppressing stroke injury (Table 1) [126]. Here, PARK7 is linked to Stroke.