Studies using the lncRNA OIP5-AS1 in a cell model of IS using HMC3 cells (microglia) and SH-SY5Y cells (human neuroblastoma) exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) mimic stroke conditions by stimulating restricted blood flow while depriving cells of oxygen and glucose, and subsequently restoring them to simulate return of blood flow. Here, OIP5 is linked to Stroke.