Several reports have shown that the over-expression of SERPINB5 (serine protease inhibitor B5) can promote PDAC metastasis [24], and the marked up-regulation of SLC6A14 (solute carrier, family 6, member 14) in pancreatic cancer leads to worse survival [25,26,27]. The gene discussed is SERPINB5; the disease is pancreatic neoplasm.